Drug Index

Mepivacaine

 
print

Mechanism :

Mepivacaine is an amide local anesthetic similar to lidocaine. Local anesthetics bind selectively to the intracellular surface of sodium channels to block influx of sodium into the axon. As a result, depolarization necessary for action potential propagation and subsequent nerve function is prevented.


Indication :

• Dental anesthesia

• Local or regional anesthesia


Contraindications :

Not for use in spinal anesthesia.


Dosing :

Local or regional anaesthesia (egg, epidural, caudal, or peripheral nerve blocks):

Maximum single or total dose given for one procedure: 5 to 6 mg/kg; only concentrations <2% should be used in children <3 years or <14 kg.

Dental anesthesia: Children and Adolescents:

Maximum dosage must be carefully calculated on the basis of patient’s weight. Manufacturer recommends a maximum dose of 6.6 mg/kg but must not exceed 270 mg as a 3% solution.


Adverse Effect :

Directly related to the blood levels of mepivacaine, route of administration, and physical status of the patient. Effects below are more likely to occur after systemic administration rather than infiltration.

Bradycardia, cardiac insufficiency, cardiovascular depression, cardiovascular stimulation, heart block, hypertension, hypotension, low cardiac output, syncope, tachycardia, ventricular arrhythmia, Anxiety, chills, confusion, convulsions, dizziness, drowsiness, excitement, loss of consciousness, increased body temperature, nervousness, paralysis, persistent anesthesia, restlessness, Diaphoresis, erythema, pruritus, urticarial, Methemoglobinemia, Anaphylactoid reaction, angioedema, hypersensitivity reaction.


Interaction :

Beta-Blockers: May increase the serum concentration of Mepivacaine. Risk C: Monitor therapy.
Bupivacaine (Liposomal): Local Anesthetics may enhance the adverse/toxic effect of Bupivacaine (Liposomal). Management: Liposomal bupivacaine should not be administered with local anesthetics.
Neuromuscular-Blocking Agents: Local Anesthetics may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents.


07/17/2019 10:26:39 Mepivacaine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0