Drug Index

Meprobamate

 
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Mechanism :

Affects the thalamus and limbic system; also appears to inhibit multineuronal spinal reflexes.


Indication :

• Management of anxiety disorders


Contraindications :

Hypersensitivity to meprobamate, related compounds, or any component of the formulation; acute intermittent porphyria.


Dosing :

Oral: Children ≥6 years: 200 to 600 mg/day in 2 to 3 divided doses.

Adolescents: 1,200 to 1,600 mg/day in 3 to 4 divided doses; Maximum: 2,400 mg/day.


Adverse Effect :

Abnormal electroencephalogram, cardiac arrhythmia, peripheral edema, palpitations, severe hypotension, Ataxia, chills, dizziness, drowsiness, euphoria, headache, dermatitis, erythema multiforme, skin rash, Stevens-Johnson syndrome, Exacerbation of porphyria, Diarrhea, nausea, proctitis, Agranulocytosis, aplastic anemia, bruise, eosinophilia, immune thrombocytopenia, Anaphylaxis, angioedema, hypersensitivity reaction, weakness, fever, bronchospasm.


Interaction :

CNS Depressants: May enhance the adverse/toxic effect of other CNS Depressants.
Opioid Analgesics: CNS Depressants may enhance the CNS depressant effect of Opioid Analgesics.
Selective Serotonin Reuptake Inhibitors: CNS Depressants may enhance the adverse/toxic effect of Selective Serotonin Reuptake Inhibitors.


07/18/2019 12:05:01 Meprobamate
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