Mequinol/Tretinoin
Mechanism :
Mequinol is a depigmenting agent.
Tretinoin may repair skin damage due to UV radiation.
Indication :
Contraindications :
Hypersensitivity, Pregnancy, women of childbearing potential.
Dosing :
<12 years old:
Safety & efficacy not established.
>12 years old:
Apply (2%/0.01%) to affected area at bedtime or evening.
Adverse Effect :
Erythema, peeling of skin, pruritus, hypopigmentation, burning, stinging sensation of skin, application site reaction, phototoxicity.
Interaction :
Tetracycline, Doxycycline: Either increases toxicity of the other by unspecified interaction mechanism. Both tretinoin and tetracyclines can cause increased intracranial pressure.
Hepatic Dose :
It has been recommended if hepatic enzymes increase to > 5-times the upper limit of normal, consideration should be given to temporarily discontinuing oral tretinoin therapy.