Drug Index

Methscopalamine

 
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Mechanism :

It is a quaternary ammonium derivative of scopolamine that exerts anticholinergic effects


Indication :

• Off-label: Peptic Ulcer Disease (adjunctive therapy)


Contraindications :

Hypersensitivity to methscopolamine, any component of the formulation, or related drugs; glaucoma; obstructive uropathy; obstructive disease of the GI tract; paralytic ileus; intestinal atony of elderly or debilitated patients.


Dosing :

Oral. 0.2 mg/kg/day OR 6 mg/sqm/day every 8 hours.


Adverse Effect :

Allergic reaction, blurred vision, cycloplegia, mydriasis, headache, dizziness, drowsiness, palpitation, tachycardia, nausea, vomiting, taste loss, urinary retention.


Interaction :

Acetylcholinesterase Inhibitors: May diminish the therapeutic effect of Anticholinergic Agents.
Anticholinergic Agents: May enhance the adverse/toxic effect of other Anticholinergic Agents.
Glucagon: Anticholinergic Agents may enhance the adverse/toxic effect of Glucagon.
Opioid Analgesics: Anticholinergic Agents may enhance the adverse/toxic effect of Opioid Analgesics.
Potassium Chloride: Anticholinergic Agents may enhance the ulcerogenic effect of Potassium Chloride.


07/15/2019 05:56:42 Methscopalamine
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