Drug Index

Scopolamine

Synonym :

Hyoscine Hydrobromide

Mechanism :

It is an anticholinergic drug used as an antiemetic and an anesthetic premedication.


Indication :

  • Nausea & vomiting
  • Aspiration prophylaxis prior to anaesthesia and intubation
  • Procedural sedation
  • Cycloplegia induction or mydriasis induction during ophthalmologic examination
  • Treatment of iritis or uveitis
  • Treatment of sialorrhea

Contraindications :

Hypersensitivity to scopolamine, belladonna alkaloids, or any component in formulation

Closed-angle glaucoma.

GI obstruction, urinary bladder neck obstruction, paralytic ileus, toxic megacolon complicating ulcerative colitis, Tachycardia secondary to cardiac insufficiency or thyrotoxicosis, Unstable cardiovascular status in acute hemorrhage, Reflux esophagitis, hiatal hernia, Mitral stenosis.


Dosing :

Nausea & vomiting and aspiration prophylaxis prior to anaesthesia and intubation:
0.006 mg/kg (6 mcg/kg) SC/IM/IV as a single dose; dose not to exceed 0.3 mg/dose.
Procedural sedation:
7 years and older: 0.32 to 0.65 mg SC/IM/IV.
3 to 6 years: 0.2 to 0.3 mg SC/IM/IV.
6 months-3 years: 0.1 to 0.15 mg SC/IM/IV.
Cycloplegia induction or mydriasis induction during ophthalmologic examination:
Instill 1 drop of 0.25% solution in eye(s) 1 hour before refraction.
Treatment of iritis or uveitis:
Instill 1 drop of 0.25% solution in affected eye(s) once, twice, or 3 times daily.
Treatment of sialorrhea:
>5 years and >15 kg: 1.5 mg transdermal patch for 2 weeks. The transdermal patches are changed twice weekly.

Adverse Effect :

Dry mouth, drowsiness, dizziness, blurred vision, withdrawal symptoms (e.g., dizziness, nausea and vomiting) if used for >3 days.


Interaction :

Potassium salts: May delay solid potassium passage through GI tract, increase risk of ulcerative/stenotic lesions (anticholinergics slow GI transit, increase local exposure to high potassium concentration).



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. Dose as in normal renal function
HDDialysed. Dose as in normal renal function
HDF/High fluxDialysed. Dose as in normal renal function
CAV/VVHDNot Dialysed. Dose as in normal renal function

Hepatic Dose :

Scopolamine should be used with caution due to an increased risk of CNS adverse effects.
08/10/2024 17:24:27 Scopolamine
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0