Drug Index

Methyl Dopa

 
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Synonym :

Methyldopa

Mechanism :

It is a centrally acing antihypertensive agent that acts on the central alpha receptors and is used in the treatment of mild to moderate hypertension.


Indication :

• Treatment of refractory hypertension

• Hypertensive crisis


Contraindications :

Active liver disease, pheochromocytoma, porphyria.


Dosing :

Hypertension:

<12 years: 2.5 mg/kg PO thrice a day

12-18 years: 10 mg/kg/day PO in 2 divided doses.

Initial doses is to be increased at intervals of 2 or more days to a maximum of 15 mg/kg 3 times daily in neonates; 5 mg/kg/day or 3 g/day in older children and adults.

Hypertensive crisis:

20-40 mg/kg/day IV in 4 divided doses. Max dose: 65 mg/kg/day or 3 g/day.


Adverse Effect :

Sedation, dizziness, depression, lethargy, dry mouth, reduced mental capacity, rash, gynecomastia, galactorrhoea, impotence, arthralgia, nasal stuffiness, weight gain and postural hypotension. Positive Coombs test, thrombocytopenia, cholestatic liver damage, bradycardia may also be seen.


Interaction :

Potentiation of other antihypertensives.
NSAIDS: Antagonise the antihypertensive effect.


07/15/2019 06:02:27 Methyl Dopa
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