Drug Index

Metoprolol

 
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Mechanism :

Metoprolol is a beta-adrenergic receptor blocking agent.


Indication :

• Hypertension

• Cyanotic spells


Contraindications :

Metoprolol is contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure. It should be avoided in asthmatics.


Dosing :

Oral: 1-2 mg/kg/day orally in 2 divided doses. Max: 6 mg/kg/day.


Adverse Effect :

Bradycardia, postural hypotension, heart failure, heart block, intermittent claudication and Raynaud’s phenomenon, dizziness, confusion, mood changes, nightmares, hallucinations, paresthesia, headache, bronchospasm, wheezing, dyspnea, hypoglycemia, purpura, thrombocytopenia, nausea, dyspepsia, flatulence, heartburn, diarrhea, constipation, tiredness, rash, pruritus, xerostomia.


Interaction :

Calcium Channel Blockers: Additive effect.
Prostaglandin Synthetase Inhibiting drugs: Decrease the hypotensive effects of beta blockers.
Catecholamine-Depleting drugs such as Reserpine: Hypotension, marked bradycardia, vertigo, syncopal attacks, or orthostatic hypotension.
Haloperidol: Hypotension and cardiac arrest.
Theophylline: Clearance is reduced.
Cimetidine: Increasing blood levels.


12/09/2019 08:56:31 Metoprolol
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