Drug Index

Miltefosine

 
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Mechanism :

Exact mechanism unknown; likely interaction with phospholipids and steroids in parasitic cell membranes, inhibition of cytochrome c oxidase (mitochondrial function), and apoptosis-like cell death.


Indication :

• Leishmaniasis: In adolescents 12 years and older weighing at least 30 kg.

• Off-label: Free-living amebae (FLA) infections, including primary amoebic meningoencephalitis (PAM) caused by Naegleria fowleri, granulomatous amoebic encephalitis caused by Balamuthia mandrillaris, and Acanthamoeba spp.


Contraindications :

Hypersensitivity to miltefosine or any component of the formulation; Sjogren-Larsson syndrome; pregnancy.


Dosing :

Oral. Use in children ≥12 years.

30 to 44 kg: 50 mg twice daily for 28 days.

≥45 kg: 50 mg 3 times daily for 28 days.


Adverse Effect :

Headache, dizziness, nausea, vomiting, diarrhea, abdominal pain, thrombocytopenia, increased serum transaminases, creatinine, pruritus, cellulitis, pyoderma, testicular pain and swelling.


Interaction :

No known significant interactions.


08/07/2019 23:29:50 Miltefosine
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