Drug Index

Muromonab CD3

 
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Mechanism :

Blocks function of CD3 in T lymphocytes.


Indication :

• Acute Allograft Rejection or Acute Graft-Vs-Host Disease Treatment


Contraindications :

Hypersensitivity to any murine-derived products, Anti-mouse Ab titres = 1:1000, Uncontrolled heart failure or fluid overload, uncontrolled hypertension, history of seizures, pregnancy, breastfeeding.


Dosing :

<30 kg: 2.5 mg IV daily x 10-14 days.

>30 kg: 5 mg IV daily x 10-14 days.

May titrate daily by 2.5 mg to achieve CD3+cells <25/cumm and serum muromonab-CD3 >800 ng/mL.


Adverse Effect :

Pyrexia, chills, dyspnea, nausea, chest pain, diarrhea, tremors, wheezing, headache, tachycardia, hypotension, vomiting, anaphylaxis.


Interaction :

Vaccines (Live): Immunosuppressants may enhance the adverse/toxic effect of live vaccines.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
08/03/2020 17:06:42 Muromonab CD3
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