Drug Index

Muromonab CD3


Mechanism :

Blocks function of CD3 in T lymphocytes.

Indication :

• Acute Allograft Rejection or Acute Graft-Vs-Host Disease Treatment

Contraindications :

Hypersensitivity to any murine-derived products, Anti-mouse Ab titres = 1:1000, Uncontrolled heart failure or fluid overload, uncontrolled hypertension, history of seizures, pregnancy, breastfeeding.

Dosing :

<30 kg: 2.5 mg IV daily x 10-14 days.

>30 kg: 5 mg IV daily x 10-14 days.

May titrate daily by 2.5 mg to achieve CD3+cells <25/cumm and serum muromonab-CD3 >800 ng/mL.

Adverse Effect :

Pyrexia, chills, dyspnea, nausea, chest pain, diarrhea, tremors, wheezing, headache, tachycardia, hypotension, vomiting, anaphylaxis.

Interaction :

Vaccines (Live): Immunosuppressants may enhance the adverse/toxic effect of live vaccines.

03/14/2020 10:15:55 Muromonab CD3
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