Drug Index

Atracurium

 
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Mechanism :

Atracurium is a nondepolarizing skeletal muscle relaxant. Nondepolarizing agents antagonize the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate.


Indication :

• As an adjunct to general anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.


Contraindications :

Atracurium is contraindicated in patients known to have a hypersensitivity to it and in neonates. Its advantage is that, it does not require any dosage adjustment in renal or hepatic disease as it spontaneously degrades in the plasma.


Dosing :

1 month to 2 years: 0.3-0.4 mg/kg IV initially followed by maintenance dose of 0.3-0.4 mg/kg as and when needed to maintain neuromuscular blockade.

>2 years (same as adults): 0.4-0.5 mg/kg IV over 1 min, followed by 0.08-0.1 mg/kg 20-45 minutes after initial dose to maintain neuromuscular block. Repeat maintenance doses every 15-25 mins as and when required.


Adverse Effect :

Flushing, erythema, itching, wheezing, bronchial secretions, pruritus, urticaria and hives.


Interaction :

Enflurane; Isoflurane; Halothane; Certain Antibiotics, especially the Aminoglycosides and Polymyxins; Lithium; Magnesium Salts; Procainamide; and Quinidine: Enhance actions of atracurium.


08/11/2019 20:52:22 Atracurium
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