Drug Index

Nivolumab

 
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Mechanism :

Nivolumab is a fully human immunoglobulin G4 (IgG4) monoclonal antibody that selectively inhibits programmed cell death-1 (PD-1) activity by binding to the PD-1 receptor to block the ligands PD-L1 and PD-L2 from binding.


Indication :

• Hodgkin lymphoma, classical

• Hepatocellular carcinoma

• Colorectal cancer, metastatic (microsatellite instability-high or mismatch repair deficient)

• Head and neck cancer, squamous cell (recurrent or metastatic)

• Melanoma

• Non-small cell lung cancer, metastatic, progressive

• Small cell lung cancer, metastatic

• Renal cell cancer, advanced


Contraindications :

Hypersensitivity to nivolumab or any component of the formulation.


Dosing :

Colorectal cancer, metastatic (Microsatellite instability-high or mismatch repair deficient; combination therapy):

≥12 years: IV: 3 mg/kg once every 3 weeks (in combination with ipilimumab) for 4 combination doses, followed by 240 mg (flat dose) once every 2 weeks (nivolumab monotherapy) until disease progression or unacceptable toxicity.

Colorectal cancer, metastatic (Microsatellite instability-high or mismatch repair deficient; single agent):

≥12 years: IV 240 mg (flat dose) once every 2 weeks until disease progression or unacceptable toxicity.


Adverse Effect :

Edema, fatigue, malaise, headache. Peripheral neuropathy, skin rash, pruritus, hyperglycemia, hyponatremia, hyperkalemia, hypocalcemia, hypertriglyceridemia, increased TSH level, diarrhea, nausea, abdominal pain, anorexia, increased serum lipases, AST, ALT, ALP & creatinine, UTI, anemia, granulocytopenia, thrombocytopenia, GVHD, antibody development, asthenia, musculoskeletal pain.


Interaction :

Belimumab: Monoclonal Antibodies may enhance the adverse/toxic effect of Belimumab.
Immunosuppressants: May diminish the therapeutic effect of Nivolumab.


07/18/2019 12:04:47 Nivolumab
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