Drug Index

Mechanism :

A reversible inhibitor of gastric and pancreatic lipases, thus inhibiting absorption of dietary fats by 30%.


Indication :

  • Obesity management

Contraindications :

Hypersensitivity to orlistat or to any component of the formulation; pregnancy; chronic malabsorption syndrome; cholestasis.


Dosing :

≥12 years:
60-120 mg 3 times daily with each main meal containing fat (during or up to 1 hour after the meal); omit dose if meal is occasionally missed or contains no fat.

Adverse Effect :

Pedal edema, headache, anxiety, fatigue, sleepiness, xeroderma, hypoglycaemia, menstrual disease, oily rectal leakage, abdominal distress, abdominal pain, steatorrhea, faecal incontinence, rectal pain, cholelithiasis, back pain, leg pain, myalgia.


Interaction :

Anticonvulsants: Orlistat may decrease the serum concentration of Anticonvulsants.
Antiretroviral Agents: Orlistat may decrease the serum concentration of Antiretroviral Agents.
Levothyroxine: Orlistat may decrease the serum concentration of Levothyroxine.
Vitamin D Analogs: Orlistat may decrease the serum concentration of Vitamin D Analogs.
Vitamins (Fat Soluble): Orlistat may decrease the serum concentration of Vitamins (Fat Soluble)



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDUnlikely to be dialysed. Dose as in normal renal function
HDF/High fluxUnlikely to be dialysed. Dose as in normal renal function
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are needed. During treatment, if signs or symptoms of liver injury occur, discontinue treatment. Some guidelines suggest avoidance of orlistat and other weight-loss medications in patients with severe hepatic disease.
09/23/2020 00:21:12 Orlistat
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