Oxymetazoline
Mechanism :
It is a selective alpha 2 agonist and a nasal decongestant that acts by causing nasal vasoconstriction.
Indication :
Contraindications :
Use with caution in patients with high blood pressure; arrhythmias; thyroid problems; diabetes; glaucoma.
Dosing :
0.05% solution 2-3 drops in each nostril 12 hourly. Oxymetazoline nasal should not be used for longer than 3 to 5 days. Longer use could cause damage to the nasal tissue and lead to chronic congestion.
Adverse Effect :
Prolonged use may cause atrophic rhinitis and anosmia. It may cause rebound congestion on stopping the drug. Other side effects include, insomnia, headache, burning, stinging, dryness, and sneezing.
Interaction :
Monoamine Oxidase Inhibitor: Should not be used if the patient has taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid, phenelzine, or tranylcypromine in the last 14 days.
Hepatic Dose :
No dose adjustment recommended.