Drug Index

PAM

 
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Synonym :

Pralidoxime


Indication :

• Antidote for the treatment of pesticides and chemicals poisoning (e.g., nerve agents) of the organophosphate class which have anticholinesterase activity.

• Control of overdosage by anticholinesterase drugs used for myasthenia gravis treatment.


Dosing :

20-40 mg/kg IV/IM dissolved in 30-50 ml of normal saline over 30 minutes once a day till symptoms subside. Can be repeated in 1-2 hours if muscle weakness is not relieved. When symptoms subside it can be administered twice a day.


Adverse Effect :

Headache, dizziness, drowsiness, seizure, visual disturbances, tachycardia, hyperventilation, muscle weakness, nausea, hypertension, pain at injection site.

Fatal: Rapid administration causes tachycardia, laryngospasm and rigidity and large doses cause neuromuscular blockade.

07/21/2019 21:49:22 PAM
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