Drug Index

Pantoprazole

 
print

Mechanism :

Suppresses gastric acid secretion by inhibiting the parietal cell membrane cell h+ k+ ATPase or proton pump demonstrates antimicrobial activity against H. Pylori.


Indication :

• Gastro-esophageal reflux disease (GERD)

• Esophageal gastric varices bleeding prophylaxis, erosive esophagitis

• Acid peptic disease

• Helicobacter pylori eradication


Contraindications :

Hypersensitivity to drug/class/component.

Substituted benzimidazole PPI e.g. esomeprazole, omeprazole or any other component.


Dosing :

Oral:

0.6 to 1.2 mg/kg/day (Max: 2.5 mg/day PO for neonates; 15 mg/day PO for patients aged

1 year; 20 mg/day PO for children aged 2 to 5 years; 40 mg/day PO for children 5 years and older. For children >40 kg, up to 80 mg/day PO (up to 2.5 mg/kg/day) has been used off-label for H. pylori eradication).

Duration of treatment is 8 weeks for erosive esophagitis (erosive GERD), non-erosive GERD and for 14 days in H.pylori eradication with combination therapy.

IV:

Limited data available for off-label IV use.


Adverse Effect :

Blood dyscrasias, hepatic impairment, hypersensitivity reaction, anaphylaxis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, pancreatitis, interstitial nephritis, rhabdomyolysis, fractures, hyponatremia, hypomagnesemia (long-term use), atrophic gastritis (long-term use), clostridium difficile associated diarrhea, headache, nausea/vomiting, diarrhea, thrombophlebitis (IV use), abdominal pain, fever, rash, dizziness, flatulence, arthralgia.


Interaction :

Interaction Characteristics:
CYP2C19 Substrate, Gastric Alkalinzers.
Contraindicated:
Nelfinavir, Rilpivirine.


07/21/2019 21:54:39 Pantoprazole
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0