Drug Index


Mechanism :

Suppresses gastric acid secretion by inhibiting the parietal cell membrane cell h+ k+ ATPase or proton pump demonstrates antimicrobial activity against H. Pylori.

Indication :

  • Gastro-esophageal reflux disease (GERD)
  • Esophageal gastric varices bleeding prophylaxis, erosive esophagitis
  • Acid peptic disease
  • Helicobacter pylori eradication

Contraindications :

Hypersensitivity to drug/class/component.

Substituted benzimidazole PPI e.g. esomeprazole, omeprazole or any other component.

Dosing :

0.6 to 1.2 mg/kg/day (Max: 2.5 mg/day PO for neonates; 15 mg/day PO for patients aged
1 year; 20 mg/day PO for children aged 2 to 5 years; 40 mg/day PO for children 5 years and older. For children >40 kg, up to 80 mg/day PO (up to 2.5 mg/kg/day) has been used off-label for H. pylori eradication).
Duration of treatment is 8 weeks for erosive esophagitis (erosive GERD), non-erosive GERD and for 14 days in H.pylori eradication with combination therapy.
Limited data available for off-label IV use.

Adverse Effect :

Blood dyscrasias, hepatic impairment, hypersensitivity reaction, anaphylaxis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, pancreatitis, interstitial nephritis, rhabdomyolysis, fractures, hyponatremia, hypomagnesemia (long-term use), atrophic gastritis (long-term use), clostridium difficile associated diarrhea, headache, nausea/vomiting, diarrhea, thrombophlebitis (IV use), abdominal pain, fever, rash, dizziness, flatulence, arthralgia.

Interaction :

Interaction Characteristics:
CYP2C19 Substrate, Gastric Alkalinzers.
Nelfinavir, Rilpivirine.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
03/23/2024 04:37:43 Pantoprazole
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