Drug Index


Mechanism :

Acts directly on amoeba; interferes with bacterial protein synthesis by binding to 30S ribosomal subunits.

Indication :

  • Intestinal amoebiasis
  • Adjunctive management of hepatic coma
  • Off-label:
  • Cryptosporidiosis-associated diarrhea in HIV-infected
  • Dientamoeba fragilis infection

Contraindications :

Hypersensitivity to paromomycin or any component of the formulation; intestinal obstruction.

Dosing :

25 to 35 mg/kg/day in 3 divided doses.
Duration: 5 to 10 days for intestinal amoebiasis, 14-21 days for cryptosporidiosis-associated diarrhea in HIV-infected patients. 7 days for Dientamoeba fragilis.

Adverse Effect :

Abdominal cramps, diarrhea, heartburn, nausea, vomiting, Enterocolitis (secondary), eosinophilia, headache.

Interaction :

No known significant interactions.

Hepatic Dose :

No oral dosage adjustment required. Use aminoglycosides with caution in patients with severe hepatic disease, as it may precipitate hepatorenal syndrome.
02/14/2024 22:12:33 Paromomycin
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