Drug Index

Paromomycin

 
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Mechanism :

Acts directly on amoeba; interferes with bacterial protein synthesis by binding to 30S ribosomal subunits.


Indication :

• Intestinal amoebiasis

• Adjunctive management of hepatic coma

Off-label:

• Cryptosporidiosis-associated diarrhea in HIV-infected

• Dientamoeba fragilis infection


Contraindications :

Hypersensitivity to paromomycin or any component of the formulation; intestinal obstruction.


Dosing :

Oral

25 to 35 mg/kg/day in 3 divided doses. Duration: 5 to 10 days for intestinal amoebiasis, 14-21 days for cryptosporidiosis-associated diarrhea in HIV-infected patients. 7 days for Dientamoeba fragilis.


Adverse Effect :

Abdominal cramps, diarrhea, heartburn, nausea, vomiting, Enterocolitis (secondary), eosinophilia, headache.


Interaction :

No known significant interactions.


07/19/2019 03:57:49 Paromomycin
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