Drug Index

PAS

 
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Synonyms :

4-Aminosalicylic acid, Para-Amino Salicylic acid

Mechanism :

It is a highly-specific bacteriostatic agent active against M. tuberculosis. Its mechanism of action is thought to be similar to the sulphonamides, a competitive antagonism with PABA.


Indication :

• Adjunctive treatment of tuberculosis used in combination with other antitubercular agents (second line agent)


Contraindications :

Hypersensitivity to aminosalicylic acid or any component of the formulation; severe renal impairment.


Dosing :

Children ≤40 kg and Adolescents <15 years: Oral: 200 to 300 mg/kg/day (usually 100 mg/kg/dose 2 to 3 times daily).

Children >40 kg and Adolescents ≥15 years: Oral: 8 to 12 g/day (usually 4 g given 2 to 3 times daily).


Adverse Effect :

Pericarditis, vasculitis, brain disease, skin rash, goitre, hypothyroidism, hypoglycaemia, agranulocytosis, haemolytic anemia, leukopenia, thrombocytopenia, hepatitis, jaundice, optic neuritis, eosinophilic pneumonitis.


Interaction :

Agents with Antiplatelet Properties (e.g., P2Y12 inhibitors, NSAIDs, SSRIs, etc.): May enhance the adverse/toxic effect of Salicylates.
Angiotensin-Converting Enzyme Inhibitors: Salicylates may enhance the nephrotoxic effect of Angiotensin-Converting Enzyme Inhibitors.
Blood Glucose Lowering Agents: Salicylates may enhance the hypoglycemic effect of Blood Glucose Lowering Agents.
Carbonic Anhydrase Inhibitors: Salicylates may enhance the adverse/toxic effect of Carbonic Anhydrase Inhibitors.
Methotrexate: Salicylates may increase the serum concentration of Methotrexate.
Sulfinpyrazone: Salicylates may decrease the serum concentration of Sulfinpyrazone.


07/18/2019 11:52:52 PAS
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