Drug Index

Pegademase

 
print

Mechanism :

Pegademase bovine is a (modified) enzyme replacement for adenosine deaminase deficiency.


Indication :

• For enzyme replacement therapy for adenosine deaminase (ADA) deficiency with SCID


Contraindications :

As preparatory or support therapy for bone marrow transplantation; severe thrombocytopenia.


Dosing :

IM: Initial dosage: 10 units/kg for the first dose, 15 units/kg for the second dose, and 20 units/kg for the third dose; administer dose every 7 days; maintenance dose: 20 units/kg/week; increase by 5 units/kg/week if necessary; maximum single dose: 30 units/kg.


Adverse Effect :

Antibody development, Autoimmune hemolytic anemia, erythema at injection site, headache, hemolytic anemia, immune thrombocytopenia, malignant lymphoma, pain at injection site, thrombocythemia, thrombocytopenia, urticaria.


Interaction :

Pegloticase: May diminish the therapeutic effect of pegylated Drug Products.
Pentostatin: May diminish the therapeutic effect of Pegademase Bovine and vice-versa.


07/17/2019 21:27:50 Pegademase
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0