Drug Index

Pegaspargase

 
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Mechanism :

Pegaspargase is a modified version of L-asparaginase, conjugated with polyethylene glycol. Asparagine depletion in leukemic cells leads to inhibition of protein synthesis and apoptosis. Asparaginase is cycle-specific for the G1 phase of the cell cycle.


Indication :

• Acute lymphoblastic leukemia as a first-line agent

• Treatment of acute lymphoblastic leukemia (ALL) in patients with hypersensitivity to native forms of L-asparaginase.


Contraindications :

History of serious allergic reactions to pegaspargase or any component of the formulation; Severe hepatic impairment


Dosing :

IM, IV: 2500 units/sqm. Administer every 14 days.


Adverse Effect :

Increased serum transaminases, Hypersensitivity reaction, thrombosis, hyperglycemia, pancreatitis, blood coagulation disorder.


Interaction :

Baricitinib: Immunosuppressants may enhance the immunosuppressive effect of Baricitinib.
Denosumab: May enhance the adverse/toxic effect of Immunosuppressants.
Leflunomide: Immunosuppressants may enhance the adverse/toxic effect of Leflunomide. Specifically, the risk for hematologic toxicity.
Pimecrolimus: May enhance the adverse/toxic effect of Immunosuppressants.
Vaccines (Live): Immunosuppressants may enhance the adverse/toxic effect of live vaccines.


07/18/2019 09:53:12 Pegaspargase
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