Drug Index

Pegfilgrastim

 
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Mechanism :

Pegfilgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Pegfilgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Pegfilgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, pegfilgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase


Indication :

• Acute leukemia receiving induction or consolidation chemotherapy


Contraindications :

Pegfilgrastim is contraindicated in conditions like Hypersensitivity to the drug.


Dosing :

1 to 12 years: 0.1 mg/kg SC (Maximum dose: 6 mg) once per chemotherapy cycle, beginning 24 to 72 hours after completion of chemotherapy.

13 to 18 years, >45 kg: 6 mg once per chemotherapy cycle, beginning 24 to 72 hours after completion of chemotherapy.


Adverse Effect :

Bone pain, allergic reactions, Respiratory distress syndrome, myalgia, arthralgia, leucocytosis.


Interaction :

Drug Interactions Not Available.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnlikely to be dialysed. Dose as in normal renal function
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

No dose adjustment recommended. If aminotransferase levels rise to greater than 5 times the upper limit of normal, therapy should be temporarily stopped or dose should be reduced.
08/05/2020 08:26:07 Pegfilgrastim
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