Drug Index

Penicillin V

 
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Synonym :

Phenoxymethylpenicillin

Mechanism :

It is an oral penicillin. It interferes with cell wall synthesis in susceptible bacteria. It is used in treatment of gram-positive infections. IT is given orally for streptococcal pharyngitis, prophylaxis for rheumatic fever and in treatment of otitis media and sinusitis.


Indication :

• Streptococcal pharyngitis

• Rheumatic fever - secondary prophylaxis

• Community-acquired bacterial pneumonia

• Pneumococcal infection prophylaxis


Contraindications :

Anaphylactic reaction to beta-lactams.


Dosing :

Oral, give 1 hour before or 2 hours after meals.

Streptococcal pharyngitis:

<5 years: 250 mg PO bid-tid x 10 days;

>5 years: 500 mg PO bid-qid x 10 days.

Rheumatic fever: Secondary prophylaxis, Pneumococcal infection prophylaxis:

<5 years: 125 mg PO bid.

>5 years: 250 mg PO bid.

Community-acquired bacterial pneumonia:

>3 months: 50-75 mg/kg/day PO divided every 6-8 hours for 7-10 days.


Adverse Effect :

Rash, eosinophilia, allergy, seizures, nausea, diarrhea, oral candidiasis, anemia, anaphylaxis, interstitial nephritis, positive coomb’s reaction.


Interaction :

Interaction Characteristics:
Alters GI flora, bactericidal activity requires bacterial growth, lowers seizure threshold.
Contraindicated:
BCG live intravesical.
Avoid/Use Alternative:
Typhoid vaccine, live.


07/14/2019 20:08:09 Penicillin V
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