Drug Index

Penicillin V

Synonym :


Mechanism :

It is an oral penicillin. It interferes with cell wall synthesis in susceptible bacteria. It is used in treatment of gram-positive infections. IT is given orally for streptococcal pharyngitis, prophylaxis for rheumatic fever and in treatment of otitis media and sinusitis.

Indication :

  • Streptococcal pharyngitis
  • Rheumatic fever - secondary prophylaxis
  • Community-acquired bacterial pneumonia
  • Pneumococcal infection prophylaxis

Contraindications :

Anaphylactic reaction to beta-lactams.

Dosing :

Oral, give 1 hour before or 2 hours after meals.
Streptococcal pharyngitis:
<5 years: 250 mg PO bid-tid x 10 days;
>5 years: 500 mg PO bid-qid x 10 days.
Rheumatic fever: Secondary prophylaxis, Pneumococcal infection prophylaxis:
<5 years: 125 mg PO bid.
>5 years: 250 mg PO bid.
Community-acquired bacterial pneumonia:
>3 months: 50-75 mg/kg/day PO divided every 6-8 hours for 7-10 days.

Adverse Effect :

Rash, eosinophilia, allergy, seizures, nausea, diarrhea, oral candidiasis, anemia, anaphylaxis, interstitial nephritis, positive coomb’s reaction.

Interaction :

Interaction Characteristics:
Alters GI flora, bactericidal activity requires bacterial growth, lowers seizure threshold.
BCG live intravesical.
Avoid/Use Alternative:
Typhoid vaccine, live.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as normal renal function
HDDialysed. Dose as in normal renal function
HDF/High fluxDialysed. Dose as in normal renal function
CAV/VVHDDialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
12/19/2023 02:32:46 Penicillin V
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