Drug Index

Pimecrolimus

 
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Mechanism :

Pimecrolimus binds to the intracellular protein FKBP-12, inhibiting calcineurin, which blocks cytokine transcription and inhibits T-cell activation.


Indication :

• Atopic dermatitis: Second-line therapy for short-term and non-continuous long-term treatment of mild to moderate atopic dermatitis in immunocompetent patients 2 years and older.

• Off-label: Intertriginous and facial psoriasis; Oral lichen planus; Vitiligo.


Contraindications :

Hypersensitivity to pimecrolimus or any component of the formulation.


Dosing :

≥2 years: Apply cream (1%) thin layer to affected area twice daily.


Adverse Effect :

Headache, fever, influenza, local burning, nasopharyngitis, bronchitis, folliculitis, acne vulgaris, impetigo, warts, hypersensitivity, sore throat, asthma.


Interaction :

CYP3A4 Inhibitors: May decrease the metabolism of Pimecrolimus.
Immunosuppressants: Pimecrolimus may enhance the adverse/toxic effect of Immunosuppressants.


07/17/2019 11:00:40 Pimecrolimus
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