Drug Index

Piperacillin Tazobactum

Mechanism :

Piperacillin and tazobactam is an injectable antibacterial combination product consisting of the semisynthetic extended spectrum penicillin effective against the gram-negative organisms like Pseudomonas and Klebsiella species and the b -lactamase inhibitor tazobactam sodium for intravenous administration. It is also effective against S.aureus, H.influenza, Enterobacter.

Indication :

  • Pseudomonas infection, not responding to other drugs
  • Klebsiella spp infections

Contraindications :

Contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or b-lactamase inhibitors.

Dosing :

80 mg/kg/dose (piperacillin component) IV 3 times daily.
100 mg/kg/dose (piperacillin component) IV 3 times daily. Max: 4 g/dose piperacillin and 4.5 g/dose piperacillin tazobactam.

Adverse Effect :

Serious and occasionally fatal anaphylactic reactions have occurred. Rarely liver disorders, blood dyscrasias and dermatological manifestations have been reported. Rarely renal failure may occur.

Interaction :

Warfarin: Possible prolonged prothrombin time with warfarin. Aminoglycosides : the mixing of beta-lactam antibiotics with aminoglycosides in vitro can result in substantial inactivation of the aminoglycoside Probenecid: administered concomitantly prolongs the half-life of piperacillin by and that of tazobactam Vecuronium: Piperacillin when used concomitantly with vecuronium has been implicated in the prolongation of the neuromuscular blockade of vecuronium Methotrexate: Limited data suggests that co-administration of methotrexate and piperacillin may reduce the clearance of methotrexate due to competition for renal secretion

Hepatic Dose :

No dosage adjustments are recommended.
01/23/2024 11:20:39 Piperacillin Tazobactum
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