Drug Index

Posaconazole

 
print

Mechanism :

Interferes with fungal cytochrome P450 (lanosterol-14a-demethylase) activity, decreasing ergosterol synthesis.


Indication :

• Prophylaxis of invasive Aspergillus and Candida infections

• Oropharyngeal candidiasis (13 years and older)


Contraindications :

Co-administration with sirolimus, ergot alkaloids, HMG-CoA reductase inhibitors that are primarily metabolized through CYP3A4, or CYP3A4 substrates that prolong the QT interval; hypersensitivity to posaconazole, other azole antifungal agents, or any component of the formulation.


Dosing :

Candida and aspergillosis prophylaxis:

≥13 years:

Oral: Suspension: 200 mg 3 times daily.

IV: Initial: 300 mg twice daily on day 1; Maintenance dose: 300 mg once daily on day 2 and thereafter.

Duration of therapy is based on recovery from neutropenia or immunosuppression.

Treatment of Oropharyngeal infection:

≥13 years: Initial: 100 mg PO twice daily on day 1. Maintenance: 100 mg OD on day 2 and thereafter for 13 days. For infections refractory to itraconazole and fluconazole, the FDA-labelled dose is 400 mg PO twice daily.

Mucocutaneous candidiasis:

≥13 years: 400 mg PO twice daily for 14 to 21 days in patients with refractory disease.

Disseminated histoplasmosis:

≥13 years: 400 mg PO twice daily for at least 12 months.


Adverse Effect :

Thrombophlebitis, hypertension, peripheral edema, headache, rigors, fatigue, skin rash, hypokalemia, hypermagnesemia, hyperglycemia, diarrhea, vomiting, nausea, anorexia, constipation, thrombocytopenia, anemia. Neutropenia, increased AST, musculoskeletal pain, cough, dyspnea, fever.


Interaction :

Antineoplastic Agents (Vinca Alkaloids): Posaconazole may enhance the adverse/toxic effect of Antineoplastic Agents (Vinca Alkaloids).
CYP3A4 Substrates: CYP3A4 Inhibitors may decrease the metabolism of CYP3A4 Substrates.
Digoxin: Posaconazole may increase the serum concentration of Digoxin.
Dihydroergotamine: Posaconazole may increase the serum concentration of Dihydroergotamine.


07/14/2019 06:53:36 Posaconazole
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0