Drug Index


Mechanism :

It is an amide derivative of procaine used in the treatment of atrial and ventricular arrhythmias.

Indication :

  • Ventricular arrhythmias
  • Supraventricular arrhythmias

Contraindications :

Hypersensitivity to drug/class/component, SLE, 2nd or 3rd degree AV block, Torsades de pointes, Congenital long QT syndrome, uncorrected Electrolyte abnormalities.

Dosing :

Use in atrial fibrillation and flutter only after the ventricular rate is stabilized.
IV: Initial loading dose of 3-6 mg/kg over 5 mins; Maximum: 100 mg/dose. May be repeated to maximum of 15 mg/kg/dose every 5-10 mins as and when required; followed by maintenance dose of 0.02-0.08 mg/kg/min IV infusion. Maximum dose: 2 g/day.

Adverse Effect :

GI irritation, drug fever, tachycardia, SLE like syndrome, hepatomegaly, positive Coomb’s test, asystole, myocardial depression, hypotension and AV block.

Interaction :

Cimetidine, Ranitidine, Amiodarone, Beta- Blockers, Trimethoprim: Procainamide adjustments required.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Normal loading dose. Maintenance dose according to response, lower doses or longer dosage intervals may be required

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. Dose as in GFR<10 mL/ min
HDDialysed. Dose as in GFR<10 mL/ min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDDialysed. Dose as in normal renal function

Hepatic Dose :

Use with caution, monitor serum procainamide and NAPA concentrations closely and adjust dose accordingly.
Moderate hepatic impairment: daily dose reduction by 1/4th is recommended.
Severe hepatic impairment: daily dose reduction by 1/2 is recommended.
01/19/2024 07:47:28 Procainamide
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0