Drug Index


Mechanism :

It is a drug with weak anticoagulant effects. It combines with heparin, forming a salt and neutralizes  anticoagulant the effect of both the drugs. It disrupts the heparin (as protamine is strongly a basic compound) antithrombin 3 complex thus preventing coagulation. It result in thromboplastin inhibitions causing decrease in thrombin activity.

Indication :

  • For the reversal of low molecular weight heparin toxicity
  • Hemorrhage associated with unfractionated heparin or LMWH therapy. (Heparin Neutralization)

Contraindications :

Fish hypersensitivity

Dosing :

For the reversal of low molecular weight heparin toxicity:
The dose of protamine required is time dependent, if less than 30 minutes has passed since LMWH has been given then the dose is 1 mg/100 units of heparin. If 30 to 60 minutes has passed administer 0.5 to 0.75 mg protamine/100 units of heparin. If 60 to 120 minutes has passed administer 0.375 to 0.5 mg/100 units of heparin. If more than 120 minutes has passed administer 0.25 to 0.375 mg/100 units of heparin.

Adverse Effect :

Bradycardia ,serious hypersensitivity reactions or anaphylaxis ,pulmonary hypertension ,pulmonary edema ,anaphylactic shock ,angioedema ,bronchospasm ,heart failure ,hypotension ,dyspnea ,wheezing ,bleeding ,urticaria ,flushing ,back pain ,rash etc

Hepatic Dose :

No dose adjustment required

01/24/2024 02:28:33 Protamine
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0