Drug Index

Protein C Concentrate

 
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Mechanism :

Converted to activated protein C (APC). APC is a serine protease which inactivates factors Va and VIIIa, limiting thrombotic formation.


Indication :

• Severe congenital protein C deficiency:


Contraindications :

No contraindications.


Dosing :

IV

Acute episode/short-term prophylaxis:

Initial dose: 100 to 120 units/kg IV. Subsequent 3 doses: 60 to 80 units/kg every 6 hours (adjust to maintain peak protein C activity of 100%). Maintenance dose: 45 to 60 units/kg every 6 or 12 hours (adjust to maintain recommended maintenance trough protein C activity levels >25%).

Long-term prophylaxis:

Maintenance dose: 45 to 60 units/kg IV every 12 hours (recommended maintenance trough protein C activity levels >25%).


Adverse Effect :

Major haemorrhage, hypersensitivity reaction, diaphoresis, injection site reaction, restlessness.


Interaction :

Agents with Antiplatelet Properties (e.g., P2Y12 inhibitors, NSAIDs, SSRIs, etc.): May enhance the anticoagulant effect of Anticoagulants.
Estrogen Derivatives and progestins: May diminish the anticoagulant effect of Anticoagulants.
Nonsteroidal Anti-Inflammatory Agents: May enhance the anticoagulant effect of Anticoagulants.
Thrombolytic Agents: May enhance the anticoagulant effect of Anticoagulants.


07/18/2019 09:33:52 Protein C Concentrate
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