Drug Index

Quinupristin/Dalfopristin

 
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Mechanism :

Inhibits bacterial protein synthesis by binding to different sites on the 50S bacterial ribosomal subunit thereby inhibiting protein synthesis.


Indication :

• Treatment of complicated skin and skin structure infections caused by methicillin susceptible Staphylococcus aureus or Streptococcus pyogenes.

Off-label:

• MRSA bacteremia

• MRSA and MDR Enterococcus faecium infective endocarditis


Contraindications :

Hypersensitivity to quinupristin, dalfopristin, other streptogramins (e.g., pristinamycin, virginiamycin), or any component of the formulation.


Dosing :

≥12 years: 7.5 mg/kg IV every 8-12 hours for at least 7 days.


Adverse Effect :

Hyperbilirubinemia, local pain, inflammation, arthralgia, myalgia, thrombophlebitis, skin rash, increased LDH, CPK & GGT, anemia.


Interaction :

Cyclosporine: Quinupristin may increase the serum concentration of Cyclosporine.

Aripiprazole: CYP3A4 Inhibitors may increase the serum concentration of Aripiprazole.


07/14/2019 06:59:06 Quinupristin/Dalfopristin
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