Drug Index

Raxibacumab

 
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Mechanism :

Raxibacumab is a recombinant human IgG1 lambda monoclonal antibody which binds and neutralizes free protective antigen (PA) component of Bacillus anthracis toxin.


Indication :

• Treatment of inhalational anthrax following exposure to Bacillus anthracis in combination with appropriate antimicrobial therapy


Contraindications :

No contraindications.


Dosing :

IV

≤15 kg: 80 mg/kg as a single dose.

>15 kg to 50 kg: 60 mg/kg as a single dose.

>50 kg: 40 mg/kg as a single dose.

Note: Administer diphenhydramine ≤1 hour prior to administration of raxibacumab to reduce the risk of infusion reactions.


Adverse Effect :

Skin rash, pain, pruritus.


Interaction :

Belimumab: Monoclonal Antibodies may enhance the adverse/toxic effect of Belimumab.


07/18/2019 09:25:24 Raxibacumab
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