Drug Index

Reserpine

 
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Mechanism :

Reduces blood pressure via depletion of sympathetic biogenic amines (norepinephrine and dopamine); also, commonly results in sedative effects.


Indication :

• Agitated psychotic states (Schizophrenia)

• Hypertension


Contraindications :

Hypersensitivity to reserpine or any component of the formulation; active peptic ulcer disease, ulcerative colitis; history of mental depression (especially with suicidal tendencies); patients receiving electroconvulsive therapy.


Dosing :

Hypertension:

0.02 mg/kg/day PO in 1-2 doses, not to exceed 0.25 mg/day.


Adverse Effect :

Bradycardia, cardiac arrhythmia, chest pain, flushing, hypotension, peripheral edema, Anxiety (paradoxical), decreased mental acuity, depression, dizziness, drowsiness, drug-induced Parkinson’s disease, anorexia, diarrhea, hyperacidity, nausea, sialorrhea, vomiting, Immune thrombocytopenia, purpura, Blurred vision, optic atrophy.


Interaction :

Alcohol (Ethyl): CNS Depressants may enhance the CNS depressant effect.
Antipsychotic Agents (Second Generation [Atypical]): Blood Pressure Lowering Agents may enhance the hypotensive effect of Antipsychotic Agents.
Barbiturates: May enhance the hypotensive effect of Blood Pressure Lowering Agents.
Hypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect.
Opioid Analgesics: CNS Depressants may enhance the CNS depressant effect of Opioid Analgesics.
Tetrabenazine: Reserpine may enhance the adverse/toxic effect of Tetrabenazine.


07/18/2019 09:45:18 Reserpine
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