Drug Index

Rifapentine

 
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Mechanism :

Inhibits DNA-dependent RNA polymerase in susceptible strains of Mycobacterium tuberculosis. Bactericidal against both intracellular and extracellular MTB organisms.


Indication :

• Latent and active tuberculosis treatment.


Contraindications :

Hypersensitivity to rifapentine, other rifamycin’s, or any component of the formulation.


Dosing :

Active TB treatment:

Use in children >12 years

Initial Treatment: 600 mg PO twice weekly for 2 months in combination with other anti-tuberculosis agents.

Continuation Treatment: 600 mg PO once weekly for 4 months in combination with other anti-tuberculosis agents.

Latent TB treatment:

Not recommended in children <2 years and those <10 kg. Give once weekly for 12 weeks (Max: 900 mg/week); administer in combination with isoniazid.

10 to 14 kg: 300 mg PO.

>14 to 25 kg: 450 mg PO.

>25 to 32 kg: 600 mg PO.

>32 to 50 kg: 750 mg PO.

>50 kg: 900 mg PO.


Adverse Effect :

Hyperuricemia, pyuria, hematuria, UTI, neutropenia, lymphocytopenia, chest pain, edema, diaphoresis, hypo/hyperglycemia, anorexia, nausea, casts in urine, hypersensitivity, leukopenia/leucocytosis, thrombocytosis/thrombocytopenia.


Interaction :

Barbiturates: Rifamycin Derivatives may increase the metabolism of Barbiturates.
Beta-Blockers: Rifamycin Derivatives may decrease the serum concentration of Beta-Blockers.
Calcium Channel Blockers: Rifamycin Derivatives may decrease the serum concentration of Calcium Channel Blockers.
CYP2C9 Substrates: Rifapentine may decrease the serum concentration of CYP2C9 Substrates.
CYP3A4 Substrates: CYP3A4 Inducers (Moderate) may decrease the serum concentration of CYP3A4 Substrates.
Estrogen Derivatives & Progestins: Rifamycin Derivatives may decrease the serum concentration of Estrogen Derivatives and progestins.
Etravirine: Rifamycin Derivatives may decrease the serum concentration of Etravirine.
HMG-CoA Reductase Inhibitors (Statins): Rifamycin Derivatives may decrease the serum concentration of HMG-CoA Reductase Inhibitors.


07/18/2019 01:49:11 Rifapentine
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