Drug Index

Rimantadine

 
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Mechanism :

Exerts its inhibitory effect on three antigenic subtypes of influenza A virus (H1N1, H2N2, H3N2) early in the viral replicative cycle, possibly inhibiting the uncoating process.


Indication :

• Influenza A virus, prophylaxis and treatment


Contraindications :

Hypersensitivity to rimantadine, other adamantanes or any component of the formulation.


Dosing :

Influenza A virus, prophylaxis:

>1 year and <40 kg: 5 mg/kg/day PO in 1 to 2 divided doses for 7 days after last known exposure. Maximum: 150 mg/day upto 9 years of age and 200 mg/day in ≥10 years.

≥40 kg: 100 mg PO twice daily for 7 days after last known exposure.

Influenza A virus, treatment:

>17 years: 100 mg PO twice daily for 5 to 7 days.


Adverse Effect :

Insomnia, lack of concentration, dizziness, nervousness, nausea, anorexia, vomiting, xerostomia, weakness.


Interaction :

Antiviral Agents: May diminish the therapeutic effect of Influenza Virus Vaccine.


08/08/2019 17:06:14 Rimantadine
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