Drug Index

Sapropterin

 
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Mechanism :

Sapropterin is a synthetic form of the cofactor BH4 (tetrahydrobiopterin) for the enzyme phenylalanine hydroxylase.


Indication :

• To reduce blood phenylalanine levels in patients with hyperphenylalaninemia caused by tetrahydrobiopterin (BH4)-responsive PKU.


Contraindications :

Hypersensitivity to sapropterin or any component of the formulation.


Dosing :

≥1 month: Initial: 10 to 20 mg/kg PO once daily. Maintenance range: 5 to 20 mg/kg once daily. Adjust after 1 month based on blood phenylalanine levels.


Adverse Effect :

Headache, rhinorrhea, diarrhea, vomiting, pharyngolaryngeal pain, cough, rhinitis.


Interaction :

Levodopa: Sapropterin may enhance the adverse/toxic effect of Levodopa.
Methotrexate: May decrease the serum concentration of Sapropterin.
Phosphodiesterase 5 Inhibitors: Sapropterin may enhance the hypotensive effect of Phosphodiesterase 5 Inhibitors.


07/21/2019 22:29:15 Sapropterin
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