Drug Index

Tetrahydrobiopterin

 
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Synonym :

Sapropterin Dihydrochloride

Mechanism :

Tetrahydrobiopterin or BH4 is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.


Indication :

• Tetrahydrobiopterin synthesis defects to control phenylalanine levels in patients with phenylketonuria.


Contraindications :

Hypersensitivity


Dosing :

1-3 mg/kg once daily, oral. Some may require upto 5-20 mg/kg/day.


Adverse Effect :

Headache, diarrhea, abdominal pain, vomiting, and nausea, dizziness, gastrointestinal bleeding, respiratory failure, joint pain, increased urination, agitation.


Interaction :

Drug Interactions Not Available.


07/19/2019 03:19:01 Tetrahydrobiopterin
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