Drug Index

Mechanism :

Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.

Indication :

  • Seasonal and perennial allergic rhinitis
  • Vasomotor rhinitis
  • Allergic conjunctivitis
  • Urticaria and angioedema.

Contraindications :

Hypersensitivity, Severe hypertension or Coronary artery disease, MAO inhibitor therapy, GI or GU obstruction, narrow angle glaucoma.

Dosing :

Oral. Dose according to pseudo ephedrine component: 4 mg/kg/day or the carbinoxamine component:
0.2-0.4 mg/kg/day.

Adverse Effect :

Anaphylaxis/anaphylactoid reaction, hemolytic anemia, thrombocytopenia, agranulocytosis, pancytopenia, leukopenia, arrhythmias, seizures, toxic psychosis, labyrinthitis, acute neuritis.

Interaction :

Potassium derivates: May delay solid potassium passage through GI tract.
Doxylamine: Combination may increase risk of CNS depression.
Anticholinergic agents: May further delay gastric emptying.

Hepatic Dose :

No dosage adjustments are recommended.
09/22/2020 12:26:20 Carbinoxamine
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0