Drug Index


Mechanism :

Cetirizine is an orally active and selective second generation H1-receptor antagonist. Cetirizine, a metabolite of hydroxyzine, is an antihistamine; its principal effects are mediated via selective inhibition of peripheral H1 receptors. It also possesses some mast cell stabilizing properties.

Indication :

  • Allergic rhinitis
  • Hay fever
  • Urticaria

Contraindications :

Cetirizine is contraindicated in those patients with a known hypersensitivity to it or any of its ingredients or hydroxyzine.

Dosing :

6-11 months:
2.5 mg PO OD.
1-6 years:
2.5 mg PO once or twice a day.
6-18 years:
2.5 mg PO once or twice a day.

Adverse Effect :

Somnolence, headache, dizziness, dry mouth.

Interaction :

No clinically significant drug interactions have been found with theophylline at a low dose, azithromycin, pseudoephedrine, ketoconazole, or erythromycin. There was a small decrease in the clearance of cetirizine with larger theophylline doses.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<105–10 mg daily

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxNot dialysed. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Children > 6 years: Do not use more than 5 mg PO OD.
Children < 6 years: Use is contraindicated.
03/20/2024 13:06:06 Cetirizine
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