Drug Index

Desloratadine

 
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Mechanism :

Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.


Indication :

• Allergic rhinitis

• Urticaria


Contraindications :

Contraindicated in patients who are hypersensitive to this medication or to any of its ingredients, or to loratadine.


Dosing :

Under 6 months: Safety and efficacy not established.

6-12 months: 1 mg; orally once daily.

1-5 years: 1.25 mg; orally once daily.

6-11 years: 2.5 mg; orally once daily.

12-18 years: 5 mg orally once daily.


Adverse Effect :

Tachycardia, edema, somnolence, fatigue, dizziness, nausea, elevated liver enzymes.


Interaction :

Additive CNS depressant: effect with other CNS depressants and alcohol.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

Dosage interval adjustment may be necessary and dose intervals may have to be increased.
04/07/2020 01:02:13 Desloratadine
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