Loratadine
Mechanism :
Loratadine is a long-acting tricyclic antihistamine with selective peripheral histamine H1-receptor antagonistic activity.
Indication :
- Urticaria
- Allergic rhinitis
Contraindications :
Loratadine is contraindicated in patients who are hypersensitive to this medication or to any of its ingredients.
Dosing :
2-6 years:
5 mg, orally every day.
>6 years:
10 mg orally, every day.
Adverse Effect :
Nausea, headache, somnolence, drowsiness, nervousness, fatigue, dry mouth, hyperkinesia, conjunctivitis, dysphonia, malaise, abdominal pain, tachycardia, syncope, alopecia, anaphylaxis, abnormal hepatic function, supraventricular tachycardia.
Interaction :
Cimetidine, Erythromycin, Ketoconazole, Quinidine, Fluconazole, Fluoxetine: Could elevate plasma loratadine levels, which could theoretically result in adverse effects.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function |
| <10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Not dialysed. Dose as in normal renal function |
| HD | Not dialysed. Dose as in normal renal function |
| HDF/High flux | Unknown dialysability. Dose as in normal renal function |
| CAV/VVHD | Unlikely to be dialysed. Dose as in normal renal function |
Hepatic Dose :
Children 6 years and older: Reduce initial dose to 10 mg PO every alternate day.
Children 2 to 5 years: Reduce initial dose to 5 mg PO every alternate day.