Drug Index

Buclizine

 
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Mechanism :

Buclizine is a piperazine antihistamine with antimuscarinic and moderate sedative properties. It is used mainly for its antiemetic action and in the treatment of migraine in combination with analgesics.


Indication :

• Prophylaxis of motion sickness

• Migraine


Contraindications :

Absolute: Hypersensitivity to Buclizine or any of its components, Neonates.

Relative: Glaucoma (angle closure or predisposition to it), gastrointestinal obstruction.


Dosing :

Migraine:

10-14 years: 6.25 mg at the start of the symptoms.

>14 years (same as adult dose): 12.5 mg at the start of the symptoms.

Motion sickness:

Adults: 25 or 50 mg given 30 min before travelling, repeated after 4-6 hours, if necessary.


Adverse Effect :

Drowsiness, dizziness, incoordination, blurred vision, urinary retention, vomiting, rash, dry mouth, headache, nausea, epigastric pain, diarrhea, weight gain.


Interaction :

CNS depressants/alcohol: Concurrent use with other CNS depressants/alcohol may potentiate the CNS depression effects of buclizine.
Anticholinergics: Concurrent use with other anticholinergics may potentiate the anticholinergic effects.
Apomorphine: Prior administration of buclizine with apomorphine decreases the emetic response to apomorphine.


08/09/2019 09:42:16 Buclizine
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