Drug Index

Doxylamine

 
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Mechanism :

Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.


Indication :

• Insomnia


Contraindications :

Hypersensitivity


Dosing :

<12 years: Not recommended

>12 years: 25 mg orally 30 min before bedtime.


Adverse Effect :

Minor anticholinergic effects.


Interaction :

Monoamine Oxidase Inhibitors (MAOIs): Prolong and intensify the anticholinergic (drying) effects of antihistamines.



Hepatic Dose :

Dosage reduction may be required as it metabolised in the liver.
06/01/2020 13:27:26 Doxylamine
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