Drug Index

Cyproheptadine

 
print

Mechanism :

Cyproheptadine is serotonin and histamine antagonist with anticholinergic and sedative effects. Antiserotonin and antihistamine drugs appear to compete with serotonin and histamine, respectively, for receptor sites.


Indication :

• Hypersensitivity reactions

• Migraine

• Loss of appetite (including Anorexia Nervosa) (off-label)


Contraindications :

Should not be used in new born or premature infants. Because of the higher risk of antihistamines for infants generally and for new-borns and premature ones in particular, antihistamine therapy is contraindicated in nursing mothers. Hypersensitivity to cyproheptadine and other drugs of similar chemical structure, monoamine oxidase inhibitor therapy, angle-closure glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bladder neck obstruction, pyloroduodenal obstruction, elderly, debilitated patients are contraindications to treatment.


Dosing :

Hypersensitivity Reaction:

<2 years: Safety and efficacy not established.

2 to 6 years: 2 mg 2-3 times a day, (Max: 12 mg a day).

7 to 14 years: 4 mg 2-3 times a day, (Max: 16 mg a day).

Migraine:

Prophylaxis:

<3 years: Safety and efficacy not established.

>3 years: 0.2-0.4 mg/kg/day PO in twice daily divided doses (Maximum dose: 0.5 mg/kg/day).

Loss of Appetite (Including Anorexia Nervosa):

<13 years: Safety and efficacy not established.

>13 years: Initially 2 mg PO 4 times a day (increase upto 8 mg 6 hourly over three weeks).


Adverse Effect :

Sedation, dizziness, disturbed coordination, confusion, restlessness, excitation, nervousness, tremor, irritability, paraesthesia, neuritis, convulsions, euphoria, hallucinations, hysteria, faintness, excessive perspiration, urticaria, photosensitivity, blurred vision, diplopia, vertigo, tinnitus, hypotension, palpitation, tachycardia, extrasystoles, anaphylactic shock.


Interaction :

MAO inhibitors: Prolong and intensify the anticholinergic effects of antihistamines.
Antihistamines: May have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.



Hepatic Dose :

No dosage adjustments are recommended.
04/07/2020 01:01:36 Cyproheptadine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0