Drug Index

Ebastine

 
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Mechanism :

Ebastine, a piperidine derivative, is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is metabolised to active metabolite, carebastine. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.


Indication :

• Allergic rhinitis

• Chronic urticaria


Contraindications :

Hypersensitivity & Cardiac arrhythmias.

Caution is advised when used in hepatic impairment, renal insufficiency, QTc interval prolongation.


Dosing :

Oral

Adults: 10-20 mg once daily.

Child >6 years: 5 mg once daily.


Adverse Effect :

Headache, dry mouth, inflammation of pharynx/nose/sinus, drowsiness, indigestion, abdominal pain, nosebleed, weakness, nausea and sleeplessness.


Interaction :

Ketoconazole, Itraconazole, Clarithromycin or Erythromycin: Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation.


08/10/2019 20:43:07 Ebastine
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