Drug Index

Erythromycin

 
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Mechanism :

Erythromycin is a macrolide antibiotic. It is bacteriostatic against most gram-positive and gram-negative organisms and used in the treatment of infections caused by chlamydia, mycoplasma, urea plasma, spirochetes and rickettsia. It is used as a prophylactic agent against ophthalmia neonatorum and pertussis.


Indication :

• Pertussis

• Penicillin allergic rheumatic fever prophylaxis

• Campylobacter infection

• Uncomplicated genital infections

• Yersinia pseudo tuberculosis infections

• Mycoplasma pneumonia

• GI dysmotility


Contraindications :

Contraindicated in patients with known hypersensitivity to erythromycin, or any other macrolide. Erythromycin is contraindicated in patients taking terfenadine, astemizole, or cisapride. Concurrent topical acne therapy should be used with caution as irritation can occur.


Dosing :

30-50 mg/kg/day orally in 3-4 divided doses; Max: 4 g/day for one to two weeks.

GI dysmotility:

10-20 mg/kg/day in 3-4 divided doses.


Adverse Effect :

Vomiting, nausea, diarrhea, abdominal pain, anorexia, hepatic dysfunction, ventricular arrhythmias (tachycardia, torsades de pointes, in patients with prolonged QT intervals), chest pain, dizziness, palpitations.


Interaction :

Theophylline: Increase in serum theophylline levels and potential theophylline toxicity.
Oral anticoagulants: Increased anticoagulant effects.
Benzodiazepines: Increase the pharmacologic effects.
Carbamazepine, Cyclosporine, Tacrolimus, Hexobarbital, Phenytoin, Alfentanil, Cisapride, Disopyramide, Lovastatin, Bromocriptine, Valproate, Terfenadine, and Astemizole: Increased serum levels.


07/15/2019 06:03:27 Erythromycin
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