Drug Index

Pseudoephedrine

 
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Mechanism :

Pseudoephedrine is an orally effective nasal decongestant with peripheral effects similar to epinephrine and central effects similar to, but less intense than, amphetamines. It has the potential for excitatory side effects. At the recommended oral dosage, it has little or no pressor effect in normotensive adults. Patients have not been reported to experience the rebound congestion sometimes experienced with frequent, repeated use of topical decongestants.


Indication :

• Common cold

• Allergic rhinitis

• Vasomotor rhinitis


Contraindications :

Contraindicated in sensitivity to pseudoephedrine or any of the other components. Patients receiving or having received MAO inhibitors in the preceding 2 weeks; known hypersensitivity to pressor amines. Patients with severe hypertension or severe coronary artery disease.


Dosing :

<2 years: Safety and efficacy not established.

2-6 years: 5-30 mg PO every 4-6 hours as and when required.

6-12 years: 30 mg PO every 4-6 hours or 4 mg/kg/day in 6 hourly divided doses; Maximum dose: 120 mg/day.

>12 years: 60 mg PO every 6 hours as and when required.


Adverse Effect :

Headache, dizziness, insomnia, tremor, confusion, CNS stimulation, muscular weakness, dry mouth, nausea, vomiting, difficulty in micturition, palpitations, tightness in the chest, syncope. Fixed drug eruption has been reported and rarely hallucinations.


Interaction :

Antidepressants, Appetite Suppressants, Amphetamine, and MAOIs: May cause a rise in blood pressure.
Antihypertensive agents e.g. Bretylium, Methyldopa and Guanethidine: May have effect partially reversed by pseudoephedrine.


07/18/2019 11:57:27 Pseudoephedrine
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