Silymarin
Synonym :
Milk Thistle
Mechanism :
It is a hepatobiliary plant product used in the treatment of infective hepatitis that acts by increasing the synthesis of glutathione in the liver, which is required for the expulsion of toxins.
Indication :
- Herb prescribed for liver disease.
Contraindications :
Hypersensitivity.
Dosing :
Safety and efficacy not established in children.
Adults:
140 mg PO TID
Children:
5-10 mg/kg/day PO in 2-3 divided doses.
Adverse Effect :
Headache, diarrhea, abdominal bloating, flatulence, loss of appetite, nausea and stomach upset.
Interaction :
No significant interactions found.
Hepatic Dose :
No dosage adjustments are recommended.