Drug Index


Mechanism :

Simethicone is an anti-flatulence agent that acts by defoaming the gastric juice and thus, prevents the gas formation. It is used to treat post-operative gastrointestinal disorders, peptic ulcer and irritable bowel syndrome.

Indication :

  • Flatulence

Contraindications :

Hypersensitivity to simethicone.

Dosing :

Give PO every 6 hours after meals and at bedtime.
<2 years: 20 mg/dose; do not exceed 240 mg/day.
2-12 years: 40 mg/dose; do not exceed 480 mg/day.
>12 years: 40-125 mg/dose; not to exceed 500 mg/day.

Adverse Effect :

Dysphagia, melena, diarrhea, nausea, vomiting, abdominal pain, headache, eructation.

Interaction :

No significant interactions found.

Hepatic Dose :

No dose adjustment recommended.
03/23/2024 05:45:13 Simethicone
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