Drug Index
Synonym :

Sodium Citrate

Mechanism :

Oral alkalinizing agent.

Indication :

  • As long-term therapy to alkalinize the urine for control and/or dissolution of uric acid and cystine calculi
  • Treatment of chronic metabolic acidosis secondary to chronic renal insufficiency or syndrome of renal tubular acidosis.

Contraindications :

Hypersensitivity to sodium citrate, citric acid, or any component of the formulation; severe renal impairment; oliguria; azotemia; untreated Addison disease; adynamia episodica hereditaria; acute dehydration; heat cramp; anuria; severe myocardial damage; hyperkalemia; sodium-restricted diet.

Dosing :

Approved for use in children 2 years and older. 1 mL of oral solution contains 1 mEq of bicarbonate and 1 mEq of sodium.

Renal tubular acidosis (RTA):

Start with 2 to 4 meq bicarbonate/kg/day (2 to 4 mL/kg/day) PO in divided doses. Range: 1-7 meq/kg/day in distal RTA and 10-20 meq/kg/day in proximal RTA.

Adverse Effect :

Tetany, metabolic alkalosis, diarrhea, nausea, vomiting.

Interaction :

Aluminium Hydroxide: Citric Acid Derivatives may increase the absorption of Aluminium Hydroxide.
Amphetamines: Alkalinizing Agents may decrease the excretion of Amphetamines.
Quinine: Alkalinizing Agents may increase the serum concentration of Quinine.

Hepatic Dose :

No dosage adjustments are recommended.
06/27/2021 08:39:53 Sodium Citrate/Citric acid
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