Drug Index

Sodium Stibogluconate

 
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Mechanism :

Exact mechanism of action is unknown. Proposed mechanisms include conversion to trivalent form of antimony that affects glucose metabolism, fatty acid beta oxidation, and adenosine triphosphate (ATP) formation.


Indication :

• Leishmaniasis: cutaneous, mucosal and visceral leishmaniasis.


Contraindications :

Hypersensitivity, Significant renal impairment; breast-feeding.


Dosing :

IM, IV: 20 mg/kg/day. Duration of therapy is 20 days for cutaneous leishmaniasis and 28 days for mucosal and visceral leishmaniasis.


Adverse Effect :

Diarrhea, nausea, vomiting, Flattened T wave, inversion T wave, prolonged Q-T interval, Headache, lethargy, malaise, Abdominal pain, anorexia, increased serum lipase and amylase, depressed bone marrow (transient), Arthralgia, myalgia.


Interaction :

Amphotericin B: May enhance the cardiotoxic effect of Sodium Stibogluconate.
QT-prolonging Agents like Antidepressants, Antipsychotics, Class 1C Anti-Arrhythmic, Kinase Inhibitors, Quinolone Antibiotics: May enhance the QTc-prolonging effect of Sodium Stibogluconate.


07/21/2019 21:53:07 Sodium Stibogluconate
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