Drug Index

Sodium Tetradecyl Sulphate

Synonym :

sodium Tetradecyl Sulfate

Mechanism :

Sodium tetradecyl sulfate (STS) is an anionic surfactant used in the sclerosant drug Sotradecol. It is commonly used in the treatment of varicose and spider veins of the leg, during the procedure of sclerotherapy. Being a detergent-based chemical, its action is on the lipid molecules in the cells of the vein wall, causing inflammatory destruction of the internal lining of the vein and thrombus formation eventually leading to sclerosis of the vein.

Indication :

  • Varicose veins
  • Treatment of upper GI bleeding due to esophageal varices.

Contraindications :

Hypersensitivity, Pregnancy, Incompetency of collateral deep veins in the legs.

Incompetency of the valves of the greater & lesser saphenous veins before ligation.

Thrombophlebitis, Tuberculosis & hyperthyroidism, prolonged recumbency Acute infections, Cardiac insufficiency, diabetes, arterial disease, Varicosities caused by pelvic neoplasia.

Dosing :

Available as 3.0%, 1.0%, 0.5%, 0.2% Solution for Injection. Pediatric dose not established.
Varicose veins:
Adults: 0.5-2 mL IV (preferably 1 mL) of 1% solution for general use & 3% solution for larger varicosities. No more than 10 mL of 3% solution/week.
Treatment of upper GI bleeding due to esophageal varices.:
Adults: Using endoscopic visualization, inject directly into the varix; the concentration of solution (varies from 1-3%) and amount (range 0.5-20 ml IV) used are dependent upon the size of the varix.

Adverse Effect :

Nausea, vomiting, deep vein thrombosis, pulmonary embolism, cough, shortness of breath, pruritus of face and extremities, redness of conjunctiva, reversible hyperpigmentation of injection site, injection site ulcer, necrosis following extravasation, immune hypersensitivity reaction, anaphylaxis.

Interaction :

Mestranol: Monitor.
No other interactions.

Hepatic Dose :

No dosage adjustments are recommended.
02/20/2024 23:13:49 Sodium Tetradecyl Sulphate
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