Drug Index

Sofosbuvir

 
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Mechanism :

It is a direct-acting antiviral agent against the hepatitis C virus, is a prodrug converted to its pharmacologically active form (GS-461203) via intracellular metabolism. It inhibits HCV NS5B RNA-dependent RNA polymerase and acts as a chain terminator.


Indication :

• Treatment of genotype 1, 2, 3, or 4 chronic hepatitis C virus (HCV) infection in adults and genotype 2 or 3 chronic HCV infection in pediatric patients =12 years or weighing =35 kg, without cirrhosis or with compensated cirrhosis.


Contraindications :

Hypersensitivity to sofosbuvir or any component of the formulation; males whose female partners may become pregnant.


Dosing :

Children and Adolescents ≥12 years or ≥35 kg: Oral

Genotype 2: 400 mg once daily with concomitant ribavirin for 12 weeks.

Genotype 3: 400 mg once daily with concomitant ribavirin for 24 weeks.


Adverse Effect :

Fatigue, headache, insomnia, chills, irritability, pruritus, skin rash, nausea, decreased appetite, diarrhea, anemia, neutropenia, thrombocytopenia, weakness, myalgia, flu like symptoms, fever, increased serum lipase, bilirubin and creatine kinase.


Interaction :

Amiodarone: Sofosbuvir may enhance the bradycardic effect of Amiodarone.
Oxcarbazepine, phenobarbital, primidone: May decrease the serum concentration of Sofosbuvir.
P-glycoprotein/ABCB1 Inducers: May decrease the serum concentration of Sofosbuvir.
P-glycoprotein/ABCB1 Inhibitors: May increase the serum concentration of P-glycoprotein/ABCB1 Substrates.
Rifabutin: May decrease the serum concentration of Sofosbuvir.


07/17/2019 20:38:04 Sofosbuvir
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